Ablavar gadofosveset trisodium

Brand name

Ablavar

Generic name

gadofosveset trisodium

Side effects of Ablavar

  • itching
  • headache
  • dizziness
  • nausea
  • unusual or unpleasant taste in your mouth
  • flushing (warmth, redness, burning, or tingly feeling under your skin)
  • injection site reactions (cold feeling, warmth, pain, bruising, redness, or burning)
  • numbness or tingling in your hands or feet
  • urinating less than usual or not at all
  • drowsiness
  • confusion
  • mood changes
  • increased thirst
  • loss of appetite
  • swelling
  • weight gain
  • shortness of breath
  • fast or uneven heart rate

Warning for Ablavar

WARNING

NEPHROGENIC SYSTEMIC FIBROSIS (NSF)

Gadolinium-based contrast agents (GBCAs) increase the risk for NSF among patients with impaired elimination of the drugs. Avoid use of GBCAs in these patients unless the diagnostic information is essential and not available with non-contras ted MRI or other modalities. NSF may result in fatal or debilitating fibrosis affecting the skin, muscle and internal organs.

The risk for NSF appears highest among patients with: chronic, severe kidney disease (GFR < 30 mL/min/1.73m²), or acute kidney injury. Screen patients for acute kidney injury and other conditions that may reduce renal function. For patients at risk for chronically reduced renal function (e.g. age > 60 years, hypertension or diabetes), estimate the glomerular filtration rate (GFR) through laboratory testing. For patients at highest risk for NSF, do not exceed the recommended ABLAVAR dose and allow a sufficient period of time for elimination of the drug from the body prior to re-administration.

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